Juventus were reduced to 10 and conceded for the first time this season in Serie A as a late Razvan Marin penalty snatched a 1-1 draw for Cagliari.
Dusan Vlahovic put Juve ahead with a penalty of his own in the 15th minute on Sunday.
Sebastiano Luperto, making his 150th appearance in Serie A, had been judged to have handled in the area after a VAR check.
Yet despite dominating the ball, with 73.7% possession, Juve were unable to find a decisive second goal, with Vlahovic guilty of squandering a fantastic chance in the 79th minute.
And they were made to pay when Marin converted from the spot after Douglas Luiz fouled Roberto Piccoli.
Juve s frustration was compounded when Francisco Conceicao picked up his second yellow card in the 89th minute, with the post then denying Adam Obert a last-gasp winner for Cagliari.
FT | | It ends in a draw at the Allianz Stadium.
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Data Debrief: Juve s defence finally breached
Juve were rocked by a season-ending injury to defender Bremer this week, albeit they looked largely untroubled until the late penalty drama.
Marin s penalty was the first time Juve have conceded in Serie A in 755 minutes of action, since Ricardo Calafiori s goal for Bologna back on May 20.
Thiago Motta will lament some wasteful finishing, with Juve having 21 shots and tallying up 2.57 expected goals (xG) to Cagliari s 1.12.